5-amino-1MQ

A. Produces Dramatic Weight Loss

5-amino-1MQ has been demonstrated to target and stimulate brown adipose tissue (BAT) activity, a critical player in fat cell metabolism and thermogenesis, responsible for burning stored fat to generate heat. Through a process known as browning, 5-amino-1MQ triggers the conversion of white fat cells into beige fat cells, enhancing their ability to burn fat and thus effectively promoting weight loss. This browning effect not only aids in reducing weight gain but also contributes to the overall shrinkage of fat cells within the body’s fat tissue, thus reducing fat stores.

Furthermore, 5-amino-1MQ has been shown to potentially enhance the basal metabolic rate, which can contribute to increased calorie burning and, consequently, support weight loss efforts. Therefore, 5-amino-1MQ emerges as a promising strategy for reversing obesity and related metabolic disorders, offering a potential means to lose weight and improve fat cell metabolism.

Evidence suggests that by shrinking fat cells, 5-amino-1MQ can significantly reduce weight, burn fat, and improve body composition:

1. In U.S. Veterans military service members, the administration of 5-amino-1MQ resulted in significant weight loss without any adverse side effects. [1]
2. In diet-induced obese mice that were maintained on a high-fat diet, the administration of an NNMT inhibitor significantly reduced body weight and white adipose tissue mass and decreased the size of adipocyte cells (cells specialized for fat storage) without any observable adverse effects, suggesting enhanced cellular metabolism of adipocytes. [2-3]
3. The administration of an NNMT inhibitor in mice on a high-fat diet (HFD) protected against fat accumulation and weight gain by augmenting cellular energy expenditure. [4]
4. Studies also showed that NNMT is increased 2-fold in the subcutaneous and abdominal adipose tissue of men and women with type II diabetes compared to healthy subjects, suggesting that the administration of NNMT inhibitors may burn fat and lose weight. [5-7]
5. A cell study found that 5-amino-1MQ was able to prevent fat accumulation and shrink fat cells, resulting in less fat tissue. [8]
6. Studies found that high levels of NNMT were often found in fat cells and were associated with impaired calorie utilization resulting in increased fat storage – a mechanism related to weight gain. [9-10]

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B. Lowers Cholesterol Levels

 

5-amino-1MQ can help lower cholesterol levels by increasing the production of NAD+ in our cells and activating the SIRT1 gene. When NAD+ levels rise, it promotes the activity of SIRT1, a gene that plays a key role in regulating our body’s metabolism. SIRT1 helps in breaking down cholesterol and reducing its buildup in the bloodstream, which ultimately leads to lower cholesterol levels. This can help lower the risk of chronic diseases such as coronary heart disease, kidney disease, and high blood pressure.

Studies show that 5-amino-1MQ’s ability to increase NAD+ and activate the SIRT1 gene can help improve cholesterol levels:

1. In diet-induced obese (DIO) mice maintained on a high-fat diet, the administration of an NNMT inhibitor lowered plasma total cholesterol levels. [3]
2. A study found that SIRT1 activation by 5-amino-1MQ resulted in the suppression of cholesterol synthesis. [11]

 

 

C. Improves Blood Sugar Levels

 

5-amino-1MQ can lower blood sugar levels by improving the body’s ability to use sugar more effectively. It does this by improving the way cells in the body respond to insulin, which is a hormone that regulates blood sugar. When cells become more responsive to insulin, they can take in and use sugar from the blood more efficiently, leading to lower blood sugar levels. This effect can be particularly helpful for people with conditions like type II diabetes, where blood sugar regulation is a concern, as it can contribute to better overall blood sugar control.

Evidence found that 5-amino-1MQ has beneficial effects on blood sugar levels:

1. In diet-induced obese (DIO) mice maintained on a high-fat diet, the administration of a potent NNMT inhibitor dramatically reduced blood sugar levels without altering food intake and without adverse side effects. [3]
2. Several studies found that NNMT plays a causative role in the development of type 2 diabetes and insulin resistance, suggesting that NNMT inhibitors may help lower the risk of the disease. [12-16]
3. In mice, 5-amino-1MQ altered how fat cells work leading to the production of palmitic acid esters of hydroxy-stearic acids (PAHSAs), a class of lipids that can reduce insulin resistance. [17]

 

 

D. Fights Inflammation

 

5-amino-1MQ can help combat inflammation by acting as an anti-inflammatory agent. It does this by reducing the production and release of molecules in the body that promote inflammation. This, in turn, helps to calm down the body’s inflammatory response and prevent it from becoming overly active. As a result, 5-amino-1MQ contributes to the reduction of inflammation, which is associated with various health issues, including chronic conditions.

Evidence suggests that the enzyme NNMT is highly associated with inflammatory conditions and related injuries, suggesting that NNMT inhibitors like 5-amino-1MQ may have anti-inflammatory effects:

1. Significantly increased levels of NNMT have been observed in the lungs and skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) with muscle wasting. [18-19]
2. Experimental studies in mice also found an increase in NNMT levels after drug-induced liver injury. [20-21]
3. A study found that NNMT production is the body’s protective compensatory response to injury, resulting in inflammatory states. [22]

 

 

E. Combats Various Cancer Types

 

5 amino 1MQ cancer-fighting properties are attributed to the peptide’s ability to disrupt the energy supply to cancer cells, making it difficult for them to grow and spread. Cancer cells often rely heavily on a process called glycolysis to fuel their rapid growth. 5-amino-1MQ interferes with this process, reducing the availability of glucose, a key energy source for cancer cells. This disruption can slow down cancer cell growth and make them more vulnerable to other treatments, potentially enhancing the effectiveness of cancer therapies and contributing to the fight against cancer.

A number of high-quality studies also suggest that excess NNMT is strongly linked with the development of various types of cancer, suggesting a potential therapeutic role for NNMT inhibitors:

1. NNMT levels are significantly increased in primary glioblastoma tumors (aggressive brain tumors) compared to normal human brain samples. [23]
2. Enhanced NNMT production is also increased in human papillary thyroid cancer cell lines. [24]
3. In renal clear cell carcinoma, the production of NNMT is also significantly increased. [25]
4. In human bladder cancer, NNMT was found to be a major regulator of cell migration. [26]
5. The NNMT protein is also increased in gastric cancers. [27-28]
6. NNMT is also identified as a novel serum tumor marker for human colorectal cancers and oral squamous cell carcinoma. [29-30]
7. NNMT knockdown (NNMT gene loss) decreased the proliferation and migration of bladder cancer cells. [31]
8. NNMT knockdown also inhibited the proliferation and/or metastasis of kidney cancer cells, pancreatic cancer cells, and oral squamous carcinoma. [32-34]
9. In non-small-cell lung cancer cells, inhibition of NNMT production resulted in suppression of tumor growth. [35]
10. Higher levels of NNMT in tumor tissues are associated with lower overall survival rates in cancer patients, suggesting that NNMT inhibitor administration may help improve survival. [36]
11. In a human oral cancer cell line, the administration of an NNMT inhibitor dramatically reduced cancer cell growth and reproduction. [37]

 

 

F. Enhances Aged Muscle Regeneration

 

5-amino 1MQ helps reverse the decline in aged muscle regeneration and promotes muscle mass by boosting the activity of satellite cells, which are essential for muscle repair and growth. In aged muscles, these satellite cells become less active, leading to muscle loss and weakness. 5-amino-1MQ rejuvenates these cells, enhancing their ability to repair and replace damaged muscle fibers. This results in improved muscle regeneration and an increase in muscle mass over time. As a result, 5-amino-1MQ holds promise as a potential solution for combating the muscle loss commonly associated with aging.

Studies suggest that 5-amino-1MQ and other NNMT inhibitors have anti-aging effects on the muscles:

1. In old mice (24 months) with acute muscle injury due to barium chloride injection, the NNMT inhibitor-treated group exhibited greater contractile function (indicative of improved muscle function) compared to the saline-treated group. [38]
2. In a mouse model of muscular dystrophy (progressive weakness and loss of muscle mass), NAD+ restoration delayed muscle deterioration and increased mouse life span. [39]
3. In mice with muscular dystrophy, replenishing NAD+ stores with dietary nicotinamide riboside supplementation significantly improved muscle and heart function. [40]
4. A study found that increased NNMT was commonly associated with muscle wasting disorders, suggesting that NNMT inhibitors like 5-amino-1MQ may provide benefits. [41]