Gonadorelin

A. Treats Testicular Atrophy

There are also studies supporting the beneficial effects of gonadorelin on testicular atrophy, a condition characterized by shrinking of the testicles:

1. 1. In infants with undescended testes, gonadorelin therapy through nasal spray significantly increased the testicular volume after 5 years. [1]
   2. In adolescents who had left varicocelectomy (removal of enlarged veins in the scrotum), gonadorelin treatment increased testicular volume. [2]

B. Improves Fertility by Increasing Testosterone Production

A number of convincing studies suggest that gonadorelin can help improve fertility in both men and women:

1. In men with steroid-induced azoospermia (absence of sperm), gonadorelin therapy resulted in increased sperm production. [3]
2. In boys and girls with delayed puberty, long-term administration with gonadorelin improved reproductive health. [4]
3. In men with testosterone deficiency, gonadorelin was found to be helpful in restoring sperm production. [5]
4. In male goats, a single dose of gonadorelin exhibited beneficial effects on testicular blood flow which in turn improved sperm production. [6]
5. In men testosterone deficiency, long-term gonadorelin therapy was successful in stimulating sexual maturation. [7]
6. In goats, gonadorelin administration promoted ovulation and resulted in a higher number of embryos. [8]
7. In dairy cattles, gonadorelin administration after insemination resulted in increased pregnancy rate. [9]
8. In cows with low sexual cycles, gonadorelin injections were found to be effective in increasing the number of the subjects’ pregnancies. [10]
9. In women, pulsatile administration of gonadorelin was successful in improving the pregnancy rate of the subjects with lesser risks than the conventional gonadotropin treatment. [11]
10. In breeder cows, conception rates became significantly high after gonadorelin injection. [12]
11. A study showed that gonadorelin treatment was effective in restoring sperm production in infertile men. [13]
12. In infertile men, gonadorelin treatment increased testosterone and sperm production. [14-17]
13.  In patients with Kallman’s syndrome (delayed or absent puberty) who failed traditional treatment, gonadorelin treatment restored sperm production. [18]
14. In adolescent boys, low-dose administration of gonadorelin induced testicular growth and sperm production. [19]
15. A study showed that gonadorelin therapy could be used to trigger testosterone and sperm production in men with sex hormone deficiency. [20-22]
16. In cows, gonadorelin treatment resulted in a higher ovulatory period rate. [23]

C. Increases Sexual Desire

Gonadorelin has also been found to increase sexual desire:

1. In camel bulls, gonadorelin administration resulted in improved sperm concentration and libido. [24]
2. In female monkeys, gonadorelin injection resulted in improved sexual behavior. [25]

D. Prevents Cancer

Evidence suggests that gonadorelin has potent anti-cancer properties:

1. In mice, gonadorelin injection resulted in the suppression of intestinal and colonic tumor growth. [26]
2. In pre-menopausal women with early and advanced breast cancer, gonadorelin therapy prevented the growth of breast cancer cells. [27]
3. A study suggested that gonadorelin can help suppress the growth of prostate cancer. [28]
4. A study showed that gonadorelin may play an important role in modulating several malignant human tumors. [29]
5. Research found that gonadorelin is safe and cost-effective and that using it for 15 years could reduce the risk of breast cancer by 70%. [30]
6. Gonadorelin has been found to reduce the growth of estrogen-sensitive cancer and boost the efficacy of receptor blocking medications. [31]
7. In postmenopausal women with high levels of estrogen, long-term GnRH treatment was associated with a reduced risk of breast cancer. [32]
8. In men with aggressive prostate cancer, gonadorelin administration has been found to produce similar efficacy to surgical removal of the testicles in preventing the spread of cancer. [33]
9. Research suggests that gonadorelin may help treat castration-resistant prostate cancer. [34]
10. When used effectively and combined with early detection, the addition of gonadorelin to chemotherapeutic drugs may help cure 99% of all prostate cancer. [35]

E. Increases Muscle Mass

Studies suggest that gonadorelin is essential for muscle health:

1. In healthy young men, administration of gonadorelin significantly improved muscle mass and strength. [36]
2. In healthy older men, monthly treatment with gonadorelin increased muscle mass and leg strength. [37]
3. A study showed that gonadorelin treatment among male subjects resulted in increased muscle mass strength. [38]
4. In healthy older men, the increase in testosterone caused by gonadorelin administration induced muscle improvements. [39]

F. Promotes Healthier Bones

Gonadorelin is also important for maintaining a healthy skeletal frame according to studies:

1. In young men with sex hormone deficiency, gonadorelin treatment resulted in increased bone mineral density. [40]
2. In patients with bone disorders caused by ovarian cysts, gonadorelin treatment increased bone mineral density. [41]
3. In women with endometriosis, a condition where the womb tissue starts to grow in other places, gonadorelin treatment combined with physical training resulted in bone formation. [42]
4. A study found that surgically-castrated men with prostate cancer who received gonadorelin treatment had lower rate of bone loss compared to the untreated group. [43]

G. Improves Mood

Studies suggest that gonadorelin can help improve mood through its antidepressant effects:

1. In women with severe premenstrual syndrome, daily intranasal administration of low-dose gonadorelin greatly reduced depression and irritability. [44]
2. In men with central hypogonadism, gonadorelin administration produced positive effects on mood by treating sexual dysfunction. [45]

H. Treats Amenorrhea

Gonadorelin can also help restore normal menstrual cycle according to clinical studies:

1. In women with amenorrhea, administration of gonadorelin produced menstruation without any side effects. [46]
2. In women with primary and secondary amenorrhea, gonadorelin treatment was extremely effective in inducing ovulation and menstruation. [47]