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PT-141

$55.00

★★★★★ 4.9 stars

Bremelanotide(PT-141) was developed from the peptide hormone Melanotan II. In initial testing, Melanotan II induced darkening of skin pigment, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction an it is effective medication in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system. It is estimated that 43% of women (30 million is the US) suffer from sexual dysfunction and 30 million men suffer from ED, with incidence increasing 2-3 fold between ages 40-70. Bremelanotide currently has no contraindications and is 80% effective in men don’t respond to Viagra or Cialis.
For women, it causes a 50% increase in sexually satisfying experiences. If FDA approved, it will have the trade name Ayleesi.

SKU: N/A Categories: ,
“Purity: >98% (HPLC on request) | Molecular Formula: C50H68N14010 Molecular Weight: 1025.2| Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys)-OH”
10mg/ml subcutaneous injection provided in a 2ml vial.
“Melanocortins in the treatment of male and female sexual dysfunction. Melanocortinergic agents are currently being investigated therapy for erectile dysfunction. Studies using animal for a possible therapeutic role in male and female sexual models have demonstrated that pre-copulatory behaviors dysfunction. These investigations were sparked by in female rats analogous to sexual arousal are evoked, and findings that systemic administration of a synthetic analog preliminary clinical data also suggest a role in promoting of alpha-MSH, MT-II, causes penile erections in a variety sexual desire and arousal in women. Based on of species, including humans. Several other bremelanotide clinical experience, administration of a melanocortinergic agents including HP-228, THIQ, and melanocortin agonist is well tolerated and not associated bremelanotide (PT 141) have since been shown to have the hypotension observed with phosphodiesterase-S erectogenic properties thought to be due to binding inhibitors currently used to treat erectile dysfunction. This to melanocortin receptors in the central nervous system, review discusses investigations of melanocortin agonists for particularly the hypothalamus. Bremelanotide, a nasally the treatment of sexual dysfunction with emphasis on administered synthetic peptide, is the only proposed sites and mechanisms of action in the central melanocortinergic agent that has been clinically studied in nervous system that appear to be involved in both males and females. Data from Phase II clinical trials of melanocortinergic modulation of sexual function. bremelanotide support the use of melanocortin based Shadiack, Annette & D Sharma, Shubh & C Earle, Dennis & Spana, Carl & J Hallam, Trevor. (2007). Melanocortins in the Treatment of Male and Female Sexual Dysfunction. Current topics in medicinal chemistry, 7. 1137-44.”

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